• WTI crude was up $3.67 per barrel to $101.67. Brent crude rose $2.10 per barrel to $110.62.
• In the grain market, June wheat futures rose 48-2 cents per bushel to $7.10 per bushel.
• Corn futures were up the 30 cent limit to $6.46 per bushel.

Except for the safe haven of U.S. treasuries and the U.S. dollar, most other commodities are getting slaughtered in the wake of the Japanese crisis.

Here are some prices of nearby contracts compared to five days ago:

• WTI crude is trading at $97.68 per barrel, down from $105.
• Wheat is at $6.89 per bushel, down for $7.89.

Every major crisis has its winners and losers. With the Japanese crisis, most prominent may be the uranium stocks. As you might guess they are getting hammered. The presumption is that governments will be reluctant to approve nuclear projects in the wake of Japan's nuclear meltdown.

Here are just a few companies and recent stock prices:

• Denison Mines (DNN): $2.55, down 74 cents. Denison is a worldwide mining and exploration company. It has two uranium waste recycling plants in the U.S.

The turmoil in North Africa and the Middle East has put pressure on the Obama Administration to resume issuing permits for deep water drilling in the Gulf of Mexico. Noble Energy (NBL) was the first to obtain a permit since the BP (BP) disaster.

Noble is an international oil and gas exploration company that operates in the U.S. and internationally. In the U.S. it has operations on the West Coast, Rocky Mountains, mid continent and the Gulf of Mexico. Its international operations are located in the Middle East, South American and West Africa.

Gas prices are rising and show no signs of coming back down. In fact the predictions are for higher prices to come. At the moment, gasoline averages $3.542 per gallon, according the the AAA motorist group, as reported by CNNMoney.

The highest recorded nationwide price was $4.114 on July 17, 2008. Forecasters are looking for the $4.00 per gallon marker to be hit by this summer.

This is the fourth update to my ranting eight months ago that acquiring six of the most hated, and most highly traded stocks with constant negative headlines would outperform the overall market. The theory has born fruit as the toxic stocks are ahead and the difference is increasing over time.

There are literally hundreds of new drugs hitting the market each year. Why write about this particular drug? The drug bears discussion because it is the first one in 50 years to treat a disease called Lupus. Lupus is an autoimmune disease in which the immune system turns against part of the body it is designated to protect. It causes debilitating joint pain, organ damage and skin rashes. Up to now the key medication used to treat Lupus are steroids.

A team of researchers from Human Genome Sciences (HGSI) headed by William Haseltine started looking at genes and their special functions. The problem was that there was no gene known to cause Lupus. So they started thinking outside the box. Instead of finding the gene first and then its function, they looked for the function then found the gene called BLyS that is elevated in Lupus. The new drug is called Benlysta.

This is indeed a dramatic move. The world's largest bondholder, Pacific Invest Management Company, dubbed Pimco, sold all of its U.S. government holdings including U.S. treasuries.

At the end of February, Pimco had $236.93 billion or 12% of its holdings in the Total Return Fund in U.S. holdings. That was cut to zero.

Applied Materials (AMAT) is the world's largest semiconductor producer. The company has diversified and is producing solar power cells, but its main revenue stream is still mainly coming from crystalline silicon technology.

The company had blowout earnings in the fiscal first quarter, with income of $506 million or 38 cents a share, up from $83 million or six cents a share a year earlier, as reported in the Wall Street Journal. Revenue rose 45% to $2.69 billion from $1.95 billion.

The game is changing. It's time to play defense. Two weeks ago the U.S. stock market was in a bullish trend with no end in sight. Now international events are taking center stage. How long the markets can ignore these events is the question of the day.

Brent crude oil is trading at $116 per barrel. This has serious implications for the U.S. economy. If you recall, when oil spiked in 2008, it was a major factor in the recession that followed. People simply could not afford the price of gas and slowed their driving dramatically. We must remember that many people commute 50 to 70 miles a day just to go to work. The money is coming out of the household budget. Some people spend more in gas than they do working, especially if they work part time.

The markets were full of contradictions last week. Take for example the turmoil in the Middle East. In past crises, investors flocked to the U.S. dollar. But not this time. The U.S. dollar futures contract fell to 76.41 last week.

Another contradiction: the U.S. jobs report was the best in two years, with 192,000 new jobs added. The stock market should have rallied strongly. Instead the Dow fell 88 points. The crises in Libya and elsewhere overshadowed the favorable jobs picture.

U.S. stocks opened the trading session with the Dow Jones Industrial Average surging 125 points at the open. The Nasdaq Composite and S&P 500 also soared over 1%. The market responded partly to weekly jobless claims figures, which plunged to a nearly three-year low.

Overseas, positive sentiment ruled the European markets today. While STOXX Europe 600 Index has advanced 0.94%, London's FTSE 100 Index moved up 1.29%.

The first Chinese hybrid car, the F3DM, will hit U.S. showrooms next year from BYD Co. Ltd. (BYD). BYD, which stands for Build Your Dream, sold 240,000 F3DMs last year and Warren Buffet likes the company so much that Berkshire Hathaway invested $230 million in BYD in 2008. In fact, the latest BYD model will be on display at Berkshire's big meeting in May, as reported in New York Times.

BYD is a diversified energy company. In addition to its hybrid models Its products include solar panels, solar shaded parking systems, home energy storage systems and charging equipment and LED lighting. BYD plans to open showrooms in the Los Angeles area.